Acta Studiorum Medicorum et Biomedicorum

Open-access, peer-reviewed journal edited by Apostolos Zarros and published semiannually by St Cuthbert Press Ltd (Stanley, England, UK)

ISSN (print): 2977-6295
ISSN (online): 2977-6309

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Acta Stud. Med. Biomed.

1(1): 13–17 (2025)

RESEARCH REPORT | open access

Comparison of the hypoprogesteronaemic effects of erythropoietin and U-74389G in an experimental model of ischaemia–reperfusion in rats

Constantinos Tsompos, Constantinos Panoulis, Aggeliki Triantafyllou, Konstantinos Pantos, Konstantinos Sfakianoudis, Konstantinos Zografos, George C. Zografos, Pantelis Antonakis, Apostolos E. Papalois*

Department of Gynaecology, General Hospital of Athens “G. Gennimatas”, Athens, Greece (CT) ▪ Second Department of Obstetrics & Gynaecology, Aretaieion Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece (CP) ▪ Department of Biological Chemistry, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece (AT) ▪ Centre for Human Reproduction, Genesis Athens Clinic, Athens, Greece (KP, KS) ▪ Second Department of Surgery, Aretaieion Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece (KZ, PA, AEP) ▪ First Department of Propaedeutic Surgery, Hippocration General Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece (GCZ)
*corresponding author (papaloisapostolos@gmail.com)

Received: 19 June 2025; Accepted: 22 June 2025; Published: 25 June 2025

DOI: 10.5281/zenodo.15739081

Full-text article: PDF

Abstract: Background: The lazaroid U-74389G is an antioxidant whose experimental assessment so far has suggested a wide variety of potential therapeutic applications. Interestingly, U-74389G has also been shown to be able to trigger hypoprogesteronaemia. Aim: The aim of this study was to record and compare the effects of U-74389G and of erythropoietin on the serum progesterone levels of rats submitted to ischaemia–reperfusion. Methodology: We applied a laparotomic clamping of the inferior aorta over the renal arteries of female Wistar rats in order to cause reversible ischaemia for 45 min. The subsequent clamp removal restored the excluded inferior aorta patency and led to reperfusion, while the assessed agents were administered (both at a dose of 10 mg/kg of body weight) at the beginning of the reperfusion phase, through an inferior vena cava catheter. Serum progesterone levels were determined at 60, 90, and 120 min after the induction of reperfusion. Results: The lazaroid U-74389G was found to exert a significant hypoprogesteronaemic effect in rats subjected to ischaemia–reperfusion; in particular, significant hypoprogesteronaemia was noted at 90 and 120 min after the commencement of the reperfusion / U-74389G administration. U-74389G was found to be 5.46-fold more hypoprogesteronaemic than erythropoietin (p<0.0001), at least within the timeframe of the herein employed experimental conditions. Conclusion: U-74389G exerts a significant hypoprogesteronaemic effect in rats undergoing ischaemia–reperfusion, and this effect is superior to that induced by erythropoietin.

Keywords: erythropoietin; ischaemia; reperfusion; serum progesterone levels; U-74389G

Tsompos C., Panoulis C., Triantafyllou A., Pantos K., Sfakianoudis K., Zografos K., Zografos G. C., Antonakis P., Papalois A. E.: Comparison of the hypoprogesteronaemic effects of erythropoietin and U-74389G in an experimental model of ischaemia–reperfusion in rats. Acta Stud. Med. Biomed. 1(1): 13–17 (2025).
https://doi.org/10.5281/zenodo.15739081

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